Introduction
Cannabis has been used throughout history for both recreational and medicinal purposes. It is an abundant source of chemical compounds, mostly known as phytocannabinoids, which have a variety of physiological effects by binding to endogenous cannabinoid receptors such as CB1 and CB2, among others.
Therapeutic properties of cannabis
Cannabis has potential therapeutic properties and its preparations have been used as traditional remedies for the treatment of pain and nausea. Additionally, synthetic cannabinoids are used clinically as analgesics, antispasmodics, antiemetics, and appetite stimulants.
Toxicity and adverse effects
While significant cannabis toxicity is rare in adults, it can lead to multiple acute and chronic adverse effects. It is important to consider both safety and potential side effects when using cannabinoid-based therapies.
Evidence and clinical use
The quality of evidence in this field has been limited by the short duration of the studies, small sample sizes, lack of control groups, and the presence of bias in the majority of the studies reviewed. More studies of better methodological quality are required to support the safe use of this therapy in other diseases.
Therapeutic use of cannabis in various conditions
Cannabis has been used as an appetite stimulant, antiemetic agent, in the treatment of neurological diseases, pain relief, as well as in the complementary treatment of certain clinical conditions. However, it is important to consider the available evidence and the appropriateness of its use in each specific case.
Safety and final considerations
It is essential to take into account the potential unwanted effects associated with the use of cannabis and synthetic cannabinoids, as well as the need for greater awareness and regulation to ensure appropriate and safe use of these therapies. The context and scientific evolution around medicinal cannabis pose opportunities and challenges that require careful and balanced attention.
